- Pre-clinical Development
- Clinical Development
- Transbuccal Insulin
- Glucagon-like-peptide (GLP-1)
- Insulin/GLP-1 Combination
- Diabetes Immunotherapy
- Tumor Vaccines
With its partner Monosol Rx, Midatech’s most advanced programme takes advantage of the fact that binding a peptide hormone to a nanoparticle alters its characteristics allowing needle free delivery of insulin across the mucosa of the cheek.
Midatech has successfully bound glucagon-like-peptide [GLP-1] to nanoparticles for the treatment of Type 2 diabetes mellitus. The company has commenced pre-clinical research in this area and has generated promising early stage results.
A combination treatment in which insulin and GLP-1 are delivered on the same nanoparticles has also been developed and showed positive results in pre-clinical studies.
As part of a €6 million EU Framework 7 consortium grant, Midatech is developing a therapeutic vaccine using its GNP technology to inhibit the autoimmune destruction of pancreatic β-cells. The project was initiated in September 2012.
This project is supported by a Spanish CDTI-grant, and focuses on the development of GNPs which include folic acid (FA) and a platinum cytotoxic compound to specifically target ovarian cancer cells.
The Company has amassed a sizable body of work demonstrating specific migration of GNPs to the brain. Optimization of the passage of GNPs through the blood-brain-barrier combined with chemotherapeutic agents will allow a new generation of therapeutic options for diseases such as glioblastomas.
Midatech has developed GNPs to specifically target the liver. Studies are currently underway to evaluate structure activity relationships with a number of payloads including doxorubicin, docetaxel and camptothecin.
Midatech is actively pursuing a therapeutic vaccine for non-small cell lung cancer. Proof-of-mechanism studies were started in 2010 to investigate the induction of tumour antigen-specific cytotoxic T-cells. The technology is designed with the potential of stimulating the immune system to fight against cancer.